Peter Kolkhof : rechercher sur Z-Library

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1

Effect of Finerenone on Chronic Kidney Disease Outcomes in Type 2 Diabetes

Bakris, George L., Agarwal, Rajiv, Anker, Stefan D., Pitt, Bertram, Ruilope, Luis M., Rossing, Peter, Kolkhof, Peter, Nowack, Christina, Schloemer, Patrick, Joseph, Amer, Filippatos, Gerasimos

Journal:

New England Journal of Medicine

Année:

2020

Fichier:

PDF, 703 KB

2020

2

Failure is an option: learning from unsuccessful proof-of-concept trials

Stefan Schäfer, Peter Kolkhof

Journal:

Drug Discovery Today

Année:

2008

Langue:

english

Fichier:

PDF, 96 KB

english, 2008

3

Molecular pharmacology of the mineralocorticoid receptor: Prospects for novel therapeutics

Peter Kolkhof, Steffen A. Borden

Journal:

Molecular and Cellular Endocrinology

Année:

2012

Langue:

english

Fichier:

PDF, 419 KB

english, 2012

4

Differentiation of Arginine Vasopressin Antagonistic Effects by Selective V2 versus Dual V2/V1a Receptor Blockade in a Preclinical Heart Failure Model

Mondritzki, Thomas, Kolkhof, Peter, Sabbah, Hani N, Gheorghiade, Mihai, Fürstner, Chantal, Schmeck, Carsten, Siedentop, Harald, Schaefer, Stefan, Truebel, Hubert

Journal:

American Journal of Therapeutics

Année:

2011

Langue:

english

Fichier:

PDF, 340 KB

english, 2011

5

Remote Left Ventricular Hemodynamic Monitoring Using a Novel Intracardiac Sensor

Mondritzki, Thomas, Boehme, Philip, White, Jason, Park, Jin Woo, Hoffmann, Jessica, Vogel, Julia, Kolkhof, Peter, Walsh, Stuart, Sandner, Peter, Bischoff, Erwin, Dinh, Wilfried, Hüser, Jörg, Truebel,

Journal:

Circulation Cardiovascular Interventions

Année:

2018

Langue:

english

Fichier:

PDF, 1.08 MB

english, 2018

6

Steroidal and non-steroidal mineralocorticoid receptor antagonists in cardiorenal medicine

Agarwal, Rajiv, Kolkhof, Peter, Bakris, George, Bauersachs, Johann, Haller, Hermann, Wada, Takashi, Zannad, Faiez

Journal:

European Heart Journal

Année:

2020

Fichier:

PDF, 1004 KB

2020

7

Identification and optimization of substituted 5-aminopyrazoles as potent and selective adenosine A1 receptor antagonists

Nils Griebenow, Lars Bärfacker, Heinrich Meier, Dirk Schneider, Nicole Teusch, Klemens Lustig, Raimund Kast, Peter Kolkhof

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2010

Langue:

english

Fichier:

PDF, 901 KB

english, 2010

8

Identification and optimization of tetrahydro-2H-3-benzazepin-2-ones as squalene synthase inhibitors

Nils Griebenow, Timo Flessner, Anja Buchmueller, Martin Raabe, Hilmar Bischoff, Peter Kolkhof

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2011

Langue:

english

Fichier:

PDF, 454 KB

english, 2011

9

Identification of 4H,6H-[2]benzoxepino[4,5-c][1,2]oxazoles as novel squalene synthase inhibitors

Nils Griebenow, Anja Buchmueller, Peter Kolkhof, Jens Schamberger, Hilmar Bischoff

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2011

Langue:

english

Fichier:

PDF, 549 KB

english, 2011

10

DNA recognition and the code

Müller-Hill, Benno, Kolkhof, Peter

Journal:

Année:

1994

Fichier:

PDF, 158 KB

1994

11

A Basic Tail Increases Repression by Dimeric Lac Repressor

Peter Kolkhof, Stefan Oehler, Regina Alex, Benno Müller-Hill

Journal:

Journal of Molecular Biology

Année:

1995

Langue:

english

Fichier:

PDF, 647 KB

english, 1995

12

Lambda cI Repressor Mutants Altered in Transcriptional Activation

Peter Kolkhof, Benno Müller-Hill

Journal:

Journal of Molecular Biology

Année:

1994

Fichier:

PDF, 898 KB

1994

13

Cardiac glycosides potently inhibit C-reactive protein synthesis in human hepatocytes

Peter Kolkhof, Andreas Geerts, Stefan Schäfer, Jan Torzewski

Journal:

Biochemical and Biophysical Research Communications

Année:

2010

Langue:

english

Fichier:

PDF, 342 KB

english, 2010

14

Overexpression of PH-4, a novel putative proline 4-hydroxylase, modulates activity of hypoxia-inducible transcription factors

Felix Oehme, Peter Ellinghaus, Peter Kolkhof, Timothy J Smith, Shyam Ramakrishnan, Joachim Hütter, Matthias Schramm, Ingo Flamme

Journal:

Biochemical and Biophysical Research Communications

Année:

2002

Langue:

english

Fichier:

PDF, 564 KB

english, 2002

15

Regulation of cyclic adenosine monophosphate release by selective β2-adrenergic receptor stimulation in human terminal failing myocardium before and after ventricular assist device support

Kassner, Astrid, Toischer, Karl, Bohms, Birte, Kolkhof, Peter, Abraham, Getu, Hasenfuβ, Gerd, Morshuis, Michiel, Schulte Eistrup, Sebastian, El-Banayosy, Aly, Gummert, Jan, Milting, Hendrik

Journal:

The Journal of Heart and Lung Transplantation

Année:

2012

Langue:

english

Fichier:

PDF, 1.18 MB

english, 2012

16

Aldosterone causes DNA damage in vitro and in kidneys of DOCA/salt rats, mediated by the mineralocorticoid receptor

Nicole Schupp, Peter Kolkhof, Nina Queisser, Lars Bärfacker, Axel Kretschmer, Elke Hartmann, Stefan Schäfer, Helga Stopper

Journal:

Toxicology Letters

Année:

2009

Langue:

english

Fichier:

PDF, 61 KB

english, 2009

17

Rationale and design of ARTS: a randomized, double-blind study of BAY 94-8862 in patients with chronic heart failure and mild or moderate chronic kidney disease

Pitt, Bertram, Filippatos, Gerasimos, Gheorghiade, Mihai, Kober, Lars, Krum, Henry, Ponikowski, Piotr, Nowack, Christina, Kolkhof, Peter, Kim, So-Young, Zannad, Faiez

Journal:

European Journal of Heart Failure

Année:

2012

Langue:

english

Fichier:

PDF, 168 KB

english, 2012

18

Finerenone, a Novel Selective Nonsteroidal Mineralocorticoid Receptor Antagonist Protects From Rat Cardiorenal Injury

Kolkhof, Peter, Delbeck, Martina, Kretschmer, Axel, Steinke, Wolfram, Hartmann, Elke, Bärfacker, Lars, Eitner, Frank, Albrecht-Küpper, Barbara, Schäfer, Stefan

Journal:

Journal of Cardiovascular Pharmacology

Année:

2014

Langue:

english

Fichier:

PDF, 1.16 MB

english, 2014

19

Specificities of three tight-binding Lac repressors

Journal:

Nucleic Acids Research

Année:

1992

Langue:

english

Fichier:

PDF, 470 KB

english, 1992

20

Dehydroepiandrosterone-Induced Phosphorylation and Translocation of FoxO1 Depend on the Mineralocorticoid Receptor

Lindschau, C., Kirsch, T., Klinge, U., Kolkhof, P., Peters, I., Fiebeler, A.

Journal:

Année:

2011

Langue:

english

Fichier:

PDF, 6.38 MB

english, 2011

21

0278 : Mineralocorticoid receptor antagonism with BR-4628 protects against renal injury induced by ischemia/reperfusion

Le Mercier, Alan, Barrera-Chimal, Jonatan, Prince, Sonia, Fadel, Fouad, El Moghrabi, Soumaya, Kolkhof, Peter, Jaisser, Frederic

Journal:

Archives of Cardiovascular Diseases Supplements

Année:

2015

Langue:

english

Fichier:

PDF, 43 KB

english, 2015

22

Effect of Finerenone on Albuminuria in Patients With Diabetic Nephropathy

Bakris, George L., Agarwal, Rajiv, Chan, Juliana C., Cooper, Mark E., Gansevoort, Ron T., Haller, Hermann, Remuzzi, Giuseppe, Rossing, Peter, Schmieder, Roland E., Nowack, Christina, Kolkhof, Peter, J

Journal:

JAMA The Journal of the American Medical Association

Année:

2015

Langue:

english

Fichier:

PDF, 520 KB

english, 2015

23

Finerenone Impedes Aldosterone-dependent Nuclear Import of the Mineralocorticoid Receptor and Prevents Genomic Recruitment of Steroid Receptor Coactivator-1

Amazit, Larbi, Le Billan, Florian, Kolkhof, Peter, Lamribet, Khadija, Viengchareun, Say, Fay, Michel R., Khan, Junaid A., Hillisch, Alexander, Lombès, Marc, Rafestin-Oblin, Marie-Edith, Fagart, Jérôme

Journal:

Journal of Biological Chemistry

Année:

2015

Langue:

english

Fichier:

PDF, 1.97 MB

english, 2015

24

Vascular Smooth Muscle Mineralocorticoid Receptor Contributes to Coronary and Left Ventricular Dysfunction After Myocardial Infarction

Gueret, Alexandre, Harouki, Najah, Favre, Julie, Galmiche, Guillaume, Nicol, Lionel, Henry, Jean-Paul, Besnier, Marie, Thuillez, Christian, Richard, Vincent, Kolkhof, Peter, Mulder, Paul, Jaisser, Fré

Journal:

Année:

2016

Langue:

english

Fichier:

PDF, 1.70 MB

english, 2016

25

0542 : Vascular smooth muscle mineralocorticoid receptor contributes to coronary and left ventricular dysfunction after myocardial infarction

Gueret, Alexandre, Harouki, Najah, Favre, Julie, Galmiche, Guillaume, Nicol, Lionel, Henry, Jean-Paul, Thuillez, Christian, Richard, Vincent, Kolkhof, Peter, Mulder, Paul, Ouvrard-Pascaud, Antoine, Ja

Journal:

Archives of Cardiovascular Diseases Supplements

Année:

2016

Langue:

english

Fichier:

PDF, 50 KB

english, 2016

26

Steroidal and Nonsteroidal Mineralocorticoid Receptor Antagonists Cause Differential Cardiac Gene Expression in Pressure Overload-induced Cardiac Hypertrophy

Grune, Jana, Benz, Verena, Brix, Sarah, Salatzki, Janek, Blumrich, Annelie, Höft, Beata, Klopfleisch, Robert, Foryst-Ludwig, Anna, Kolkhof, Peter, Kintscher, Ulrich

Journal:

Journal of Cardiovascular Pharmacology

Année:

2016

Langue:

english

Fichier:

PDF, 1.03 MB

english, 2016

27

Nonsteroidal antagonists of the mineralocorticoid receptor

Kolkhof, Peter, Nowack, Christina, Eitner, Frank

Journal:

Current Opinion in Nephrology & Hypertension

Année:

2015

Langue:

english

Fichier:

PDF, 2.27 MB

english, 2015

28

[Handbook of Experimental Pharmacology] || Steroidal and Novel Non-steroidal Mineralocorticoid Receptor Antagonists in Heart Failure and Cardiorenal Diseases: Comparison at Bench and Bedside

Année:

2016

Langue:

english

Fichier:

PDF, 731 KB

english, 2016

29

A Randomized Controlled Study of Finerenone vs. Eplerenone in Japanese Patients With Worsening Chronic Heart Failure and Diabetes and/or Chronic Kidney Disease

Sato, Naoki, Ajioka, Masayoshi, Yamada, Takahisa, Kato, Masaharu, Myoishi, Masafumi, Yamada, Takashi, Kim, So-Young, Nowack, Christina, Kolkhof, Peter, Shiga, Tsuyoshi

Journal:

Circulation Journal

Année:

2016

Langue:

english

Fichier:

PDF, 965 KB

english, 2016

30

A randomized controlled study of finerenone versus placebo in Japanese patients with type 2 diabetes mellitus and diabetic nephropathy

Katayama, Shigehiro, Yamada, Daishiro, Nakayama, Mikihiro, Yamada, Takashi, Myoishi, Masafumi, Kato, Masaharu, Nowack, Christina, Kolkhof, Peter, Yamasaki, Yoshimitsu

Journal:

Journal of Diabetes and its Complications

Année:

2017

Langue:

english

Fichier:

PDF, 386 KB

english, 2017

31

Benefit of Mineralocorticoid Receptor Antagonism in AKI: Role of Vascular Smooth Muscle Rac1

Barrera-Chimal, Jonatan, André-Grégoire, Gwennan, Nguyen dinh Cat, Aurelie, Lechner, Sebastian M., Cau, Jérôme, Prince, Sonia, Kolkhof, Peter, Loirand, Gervaise, Sauzeau, Vincent, Hauet, Thierry, Jais

Journal:

Journal of the American Society of Nephrology

Année:

2017

Langue:

english

Fichier:

PDF, 1.88 MB

english, 2017

32

Nonsteroidal Mineralocorticoid Receptor Antagonist Finerenone Protects Against Acute Kidney Injury–Mediated Chronic Kidney DiseaseNovelty and Significance

Lattenist, Lionel, Lechner, Sebastian M., Messaoudi, Smail, Le Mercier, Alan, El Moghrabi, Soumaya, Prince, Sonia, Bobadilla, Norma A., Kolkhof, Peter, Jaisser, Frédéric, Barrera-Chimal, Jonatan

Journal:

Année:

2017

Langue:

english

Fichier:

PDF, 1.49 MB

english, 2017

33

30 YEARS OF THE MINERALOCORTICOID RECEPTOR: Mineralocorticoid receptor antagonists: 60 years of research and development

Kolkhof, Peter, Bärfacker, Lars

Journal:

Journal of Endocrinology

Année:

2017

Langue:

english

Fichier:

PDF, 1.58 MB

english, 2017

34

Lipid droplet subset targeting of the Drosophila protein CG2254/dmLdsdh1

Thul, Peter J., Tschapalda, Kirsten, Kolkhof, Petra, Thiam, Abdou Rachid, Oberer, Monika, Beller, Mathias

Journal:

Journal of Cell Science

Année:

2017

Langue:

english

Fichier:

PDF, 3.69 MB

english, 2017

35

Comments on: Lyubarova, R. and Gosmanova, E.O. Mineralocorticoid Receptor Blockade in End-Stage Renal Disease. Current Hypertension Reports, 2017. 19(5)

Gay, Alain, Kolkhof, Peter

Journal:

Current Hypertension Reports

Année:

2017

Langue:

english

Fichier:

PDF, 894 KB

english, 2017

36

Aldosterone Target NGAL (Neutrophil Gelatinase–Associated Lipocalin) Is Involved in Cardiac Remodeling After Myocardial Infarction Through NFκB Pathway

Martínez-Martínez, Ernesto, Buonafine, Mathieu, Boukhalfa, Ines, Ibarrola, Jaime, Fernández-Celis, Amaya, Kolkhof, Peter, Rossignol, Patrick, Girerd, Nicolas, Mulder, Paul, López-Andrés, Natalia, Ouvr

Journal:

Année:

2017

Langue:

english

Fichier:

PDF, 1.23 MB

english, 2017

37

Transcutaneous glomerular filtration rate measurement in a canine animal model of chronic kidney disease

Mondritzki, Thomas, Steinbach, Sarah M.L., Boehme, Philip, Hoffmann, Jessica, Kullmann, Maximilian, Schock-Kusch, Daniel, Vogel, Julia, Kolkhof, Peter, Sandner, Peter, Bischoff, Erwin, Hüser, Jörg, Di

Journal:

Journal of Pharmacological and Toxicological Methods

Année:

2017

Langue:

english

Fichier:

PDF, 993 KB

english, 2017

38

The myeloid mineralocorticoid receptor controls inflammatory and fibrotic responses after renal injury via macrophage interleukin-4 receptor signaling

Barrera-Chimal, Jonatan, Estrela, Gabriel R., Lechner, Sebastian M., Giraud, Sébastien, El Moghrabi, Soumaya, Kaaki, Shiem, Kolkhof, Peter, Hauet, Thierry, Jaisser, Frédéric

Journal:

Kidney International

Année:

2018

Langue:

english

Fichier:

PDF, 2.39 MB

english, 2018

39

Short- and long-term administration of the non-steroidal mineralocorticoid receptor antagonist finerenone opposes metabolic syndrome-related cardio-renal dysfunction

Lachaux, Marianne, Barrera-Chimal, Jonatan, Nicol, Lionel, Rémy-Jouet, Isabelle, Renet, Sylvanie, Dumesnil, Anais, Wecker, Didier, Richard, Vincent, Kolkhof, Peter, Jaisser, Frederic, Ouvrard-Pascaud,

Journal:

Diabetes, Obesity and Metabolism

Année:

2018

Langue:

english

Fichier:

PDF, 1.08 MB

english, 2018

40

The novel mineralocorticoid receptor antagonist finerenone attenuates neointima formation after vascular injury

Dutzmann, Jochen, Musmann, Robert-Jonathan, Haertlé, Marco, Daniel, Jan-Marcus, Sonnenschein, Kristina, Schäfer, Andreas, Kolkhof, Peter, Bauersachs, Johann, Sedding, Daniel G., Alvarez de la Rosa, Di

Journal:

Année:

2017

Langue:

english

Fichier:

PDF, 5.98 MB

english, 2017

41

Corticosteroid receptors adopt distinct cyclical transcriptional signatures

Le Billan, Florian, Amazit, Larbi, Bleakley, Kevin, Xue, Qiong-Yao, Pussard, Eric, Lhadj, Christophe, Kolkhof, Peter, Viengchareun, Say, Fagart, Jérôme, Lombès, Marc

Journal:

The FASEB Journal

Année:

2018

Langue:

english

Fichier:

PDF, 1.01 MB

english, 2018

42

Biotransformation of Finerenone, a Novel Nonsteroidal Mineralocorticoid Receptor Antagonist, in Dogs, Rats, and Humans, In Vivo and In Vitro

Gerisch, Michael, Heinig, Roland, Engelen, Anna, Lang, Dieter, Kolkhof, Peter, Radtke, Martin, Platzek, Johannes, Lovis, Kai, Rohde, Gabriele, Schwarz, Thomas

Journal:

Drug Metabolism and Disposition

Année:

2018

Langue:

english

Fichier:

PDF, 702 KB

english, 2018

43

New pulmonary hypertension model in conscious dogs to investigate pulmonary-selectivity of acute pharmacological interventions

Mondritzki, Thomas, Boehme, Philip, Schramm, Lena, Vogel, Julia, Mathar, Ilka, Ellinghaus, Peter, Kolkhof, Peter, Bischoff, Erwin, Hüser, Jörg, Dinh, Wilfried, Sandner, Peter, Truebel, Hubert

Journal:

European Journal of Applied Physiology

Année:

2018

Langue:

english

Fichier:

PDF, 1.60 MB

english, 2018

44

Finerenone Attenuates Endothelial Dysfunction and Albuminuria in a Chronic Kidney Disease Model by a Reduction in Oxidative Stress

González-Blázquez, Raquel, Somoza, Beatriz, Gil-Ortega, Marta, Martín Ramos, Miriam, Ramiro-Cortijo, David, Vega-Martín, Elena, Schulz, Angela, Ruilope, Luis Miguel, Kolkhof, Peter, Kreutz, Reinhold,

Journal:

Frontiers in Pharmacology

Année:

2018

Langue:

english

Fichier:

PDF, 4.92 MB

english, 2018

45

The non-steroidal mineralocorticoid receptor antagonist finerenone prevents cardiac fibrotic remodeling

Lavall, Daniel, Jacobs, Nadine, Mahfoud, Felix, Kolkhof, Peter, Böhm, Michael, Laufs, Ulrich

Journal:

Biochemical Pharmacology

Année:

2019

Langue:

english

Fichier:

PDF, 1.53 MB

english, 2019

46

The non-steroidal mineralocorticoid receptor antagonist finerenone prevents cardiac fibrotic remodeling

Lavall, Daniel, Jacobs, Nadine, Mahfoud, Felix, Kolkhof, Peter, Böhm, Michael, Laufs, Ulrich

Journal:

Biochemical Pharmacology

Année:

2019

Fichier:

PDF, 1.53 MB

2019

47

Population Pharmacokinetic and Exposure–Response Analysis of Finerenone: Insights Based on Phase IIb Data and Simulations to Support Dose Selection for Pivotal Trials in Type 2 Diabetes with Chronic Kidney Disease

Snelder, Nelleke, Heinig, Roland, Drenth, Henk-Jan, Joseph, Amer, Kolkhof, Peter, Lippert, Jörg, Garmann, Dirk, Ploeger, Bart, Eissing, Thomas

Journal:

Clinical Pharmacokinetics

Année:

2019

Langue:

english

Fichier:

PDF, 1.17 MB

english, 2019

48

Population Pharmacokinetic and Exposure–Response Analysis of Finerenone: Insights Based on Phase IIb Data and Simulations to Support Dose Selection for Pivotal Trials in Type 2 Diabetes with Chronic Kidney Disease

Snelder, Nelleke, Heinig, Roland, Drenth, Henk-Jan, Joseph, Amer, Kolkhof, Peter, Lippert, Jörg, Garmann, Dirk, Ploeger, Bart, Eissing, Thomas

Journal:

Clinical Pharmacokinetics

Année:

2019

Fichier:

PDF, 1.17 MB

2019

49

Design and Baseline Characteristics of the Finerenone in Reducing Kidney Failure and Disease Progression in Diabetic Kidney Disease Trial

Bakris, George L., Agarwal, Rajiv, Anker, Stefan D., Pitt, Bertram, Ruilope, Luis M., Nowack, Christina, Kolkhof, Peter, Ferreira, Anna C., Schloemer, Patrick, Filippatos, Gerasimos

Journal:

American Journal of Nephrology

Année:

2019

Langue:

english

Fichier:

PDF, 241 KB

english, 2019

50

Design and Baseline Characteristics of the Finerenone in Reducing Cardiovascular Mortality and Morbidity in Diabetic Kidney Disease Trial

Ruilope, Luis M., Agarwal, Rajiv, Anker, Stefan D., Bakris, George L., Filippatos, Gerasimos, Nowack, Christina, Kolkhof, Peter, Joseph, Amer, Mentenich, Nicole, Pitt, Bertram

Journal:

American Journal of Nephrology

Année:

2019

Langue:

english

Fichier:

PDF, 286 KB

english, 2019